Toll-Like Receptor 9-Dependent, but CD4 Bound to Oligonucleotides Facilitate Antigenic Epitopes Fused to Cationic Peptide
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چکیده
منابع مشابه
Activation of APCs through CD40 or Toll-like receptor 9 overcomes tolerance and precipitates autoimmune disease.
Some autoreactive T cells normally escape thymic selection and persist in the periphery. This is true of myelin-reactive CD4(+) T cells, the effectors of experimental autoimmune encephalomyelitis (EAE) in laboratory animals and the presumed mediators of multiple sclerosis in humans. Nonetheless, most individuals do not succumb to autoimmune disease. There is growing evidence that while peripher...
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